What is this medicine?

PROTAMINE (PROH tuh meen) is used to treat heparin overdose.

How should I use this medicine?

This medicine is for slow infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

• breathing problems

• chest pain or tightness

• dizziness

• feeling faint or lightheaded, falls

• flushing or feeling of warmth

• nausea, vomiting

• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• gum bleeding or nosebleeds

• unusual tiredness

What may interact with this medicine?

• heparin

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• an unusual or allergic reaction to protamine, fish, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.